NOVEL NEXT Chapter 27 Metformin
99 source points don’t seem so out of reach.
It seems that as long as you work hard, you can still collect it.
Shit!
Lu Liang knows better than anyone how difficult it is to obtain source points.
If source points were really as easy to collect as imagined, he wouldn't have gone to such great lengths to collect them in the first place.
You know, it took him two months of study to collect 0.3 source points.
0.3!
Bai Shuke's huge sales only allowed him to collect 1.1 source points.
Adding the two together, we can barely get together 1.4 source points.
99 source points, how many drugs must be sold to collect them, and this is only if they are collected and not used.
Based on the current situation, I am afraid it will take an eternity to collect these 99 source points.
Looking at the Akilon Sai Injection on the interface, Lu Liang shook his head, feeling a little regretful.
What a great drug. If this drug could be made affordable, I don’t know how many people could be saved from illness.
However, this is still far away from him now, and it is not a question that he can think about now.
This kind of thing can only be done step by step, and we will talk about it when we have the opportunity in the future.
Lu Liang returned his attention to type 2 diabetes.
Only 0.7 source points are needed to analyze liraglutide, which is undoubtedly good news for Lu Liang.
The 0.3 source points saved can also be used to analyze drugs next time.
Lu Liang didn't think much and directly chose to analyze the medicine.
There was a bang sound.
The feeling of having his head knocked off hit him again, because this was not the first time for Lu Liang, so he was very experienced.
A large amount of information was forcefully poured into Lu Liang's mind.
After fully digesting this information, Lu Liang opened his eyes with a hint of joy in his expression.
The drug he analyzed this time is exactly a drug known as the miraculous drug for lowering blood sugar.
Metformin!
One of the main reasons why metformin is known as a miracle drug for lowering blood sugar is its extremely low price!
Liraglutide, which is also effective in treating type 2 diabetes, sells for 300 yuan per ml.
But metformin?
As long as the technology is mature and mass production can be achieved, the price of metformin will only be 3 yuan per box!
A box of 48 tablets!
That's almost enough for a patient for half a month.
It's almost as cheap as vitamin tablets.
In terms of price, metformin almost crushes liraglutide.
Lu Liang didn't think too much. He took out a piece of white paper from his backpack and began to draw the drug synthesis route of metformin on the white paper.
Because his current level is lv2, this analysis directly provided him with two different metformin drug synthesis routes.
Lu Liang naturally chose one of the simpler and more convenient drug synthesis routes.
After all, if the synthesis process is too complex, it will not be conducive to large-scale production by pharmaceutical companies.
Add 20g of raw material dicyandiamide solid to the container, then add 40ml of solvent cyclohexanol, then add 20.7g of dimethylamine hydrochloride solid, and then add 20ml of solvent cyclohexanol.
Gradient experiments show that when the ratio of the raw materials dicyandiamide and dimethylamine reaches 1:1, the total yield of the synthetic drug can reach the maximum.
Lu Liang's thoughts were clear in his mind, as if these craftsmanship had been deeply imprinted in his mind.
The second step is to install a reflux condenser tube, heat the glycerin bath to 120°C until all the reactants are dissolved, and then start refluxing after the temperature reaches 130°C for 1 hour, and the reactants begin to appear needle-like crystals.
At this time, continue heating and stirring. Stop heating when the mother liquid in the container is clear. At this time, the reactants in the container are solid and liquid. After natural cooling to about 90°C, pour out the liquid layer, add 20 mL of solvent and repeat the previous operation.
When cooled to the previous temperature, the product was filtered while hot, and the precipitate was washed twice with 95% ethanol solution, 10 mL each time, and drained.
At this time, metformin hydrochloride can be obtained.
Of course, the metformin hydrochloride at this time is only a crude product, and the next thing to do is to purify the drug.
Blend water: 95% ethanol solvent in a ratio of 1:5. The amount of solvent is 4 times that of crude metformin hydrochloride. 1kg of crude metformin hydrochloride requires 4kg of solvent for washing. Heat to 70°C with stirring to completely dissolve the crude product.
Leave it overnight, and a large amount of white needle-like crystals will precipitate and then be filtered. The crystals will be washed three times with cold 95% ethanol, 10 ml each time. The washed product will be dried in a vacuum drying oven at 120°C for 5 hours.
What you get now is the real metformin.
Lu Liang drew the metformin drug synthesis route on paper in one breath and marked the various reaction conditions one by one.
After completing the synthesis route of metformin, Lu Liang stretched hard.
According to the old procedure, the next step is to ask the mentor Ji Hong for help to synthesize the drug, and then the experiment can begin.
Before leaving the library, Lu Liang simply packed up the things on the table and walked towards Ji Hong's office.
Lu Liang arrived at the teaching building with ease and walked up the stairs.
When he was about to reach Ji Hong's office, Lu Liang suddenly stopped.
Because he found that at this time, there was a professional woman wearing black formal clothes standing at the door of Ji Hong's office.
The woman wore delicate light makeup, which made her already young appearance look even more outstanding, and she was holding a piece of information in her arms.
Lu Liang's eyes swept over the woman's body without leaving a trace, and finally landed on the work badge on the woman's chest.
I saw the name of the company and the woman - Kangsheng Pharmaceutical, Zhang Ya - printed on the work sign.
Is it a pharmaceutical company that came to Ji Hong to discuss cooperation?
Lu Liangzhong silently thought about it. In China, it is relatively common for university professors to cooperate with companies.
Generally, when a company is not strong enough to produce a certain product, it often goes to the university to find professors in the professional research field for help.
In China, professors from schools are allowed to cooperate with domestic companies to take over this type of research, which is also a horizontal topic.
The income generated from horizontal projects will also be used by professors as scientific research funds.
With Ji Hong's status in the industry, there are naturally no shortage of companies coming to him for cooperation.
However, since the drug Bai Shuke was launched, Ji Hong has stopped taking on those horizontal projects, because the income brought by Bai Shuke has been enough to fill the scientific research funds of the research team.
Lu Liang did not pay too much attention to Zhang Ya. He walked around Zhang Ya and was about to reach out and knock on the office door.
However, just when Lu Liang raised his hand, Zhang Ya, who was waiting at the door of the office, suddenly spoke: Are you an undergraduate majoring in pharmacy?