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Chapter 73 Atropine
Chapter 73 Atropine
Knowing that four firefighters were unfortunately poisoned while performing their duties, Liu Tangchun immediately rushed to the emergency room to deploy work.
Unlike other types of illness, acute organophosphate inhalation poisoning can cause very severe respiratory and neurological damage.After organic phosphorus enters the blood through the lungs, it will inhibit acetylcholinesterase in the human body.The main function of acetylcholinesterase is to degrade acetylcholine.
Acetylcholine is a special substance that mainly acts on several special nervous systems in the human body.The sweat glands secreting nerves that control sweat secretion, all parasympathetic nerves, preganglionic fibers of sympathetic nerves, etc. transmit information through acetylcholine.The role of acetylcholinesterase is to terminate these signal transmissions at the appropriate time.
However, after the degradation function of acetylcholinesterase is prevented under the interference of organic phosphorus, excess acetylcholine is flooded in the nerves, and the secretion concentration is still increasing.Eventually, it will trigger systemic choline nerve excitement, and there is only one result after excessive excitement-failure.
The main cause of death of organophosphate poisoning is respiratory failure and coma caused by overexcited nerves.To rescue people from poisoning symptoms, it is first necessary to get out of the poison environment, and then immediately use anticholinergic drugs to help the body hydrolyze excess acetylcholine in the nervous system.
Atropine is the drug of choice for clinical rescue of organophosphate poisoning.
Atropine is usually used in rescue to relieve visceral colic, including gastrointestinal spasms, as well as sinus bradycardia and atrioventricular duct obstruction.Atropine extracted from belladonna or datura can block the response of choline nerves to acetylcholine, thereby preventing the over-excitation of choline nerves.
The reason why Liu Tangchun mobilized all the people to go to the emergency room to assign work was because of a somewhat speechless reason.
The dose of atropine injection produced by pharmaceutical factories is really too small, and the common specification of atropine injection is 0.5mg/1ml.In order to achieve the blocking effect, a patient needs at least 400 mg of atropine per hour, that is, at least 800 bottles of atropine injection are enough.
Large doses of atropine injections have not been produced for many years.The usual clinical use of atropine is mainly to take advantage of its spasmodic effect.Large doses of atropine injections do not seem to be necessary - after all, there are so few cases of organophosphate poisoning.
"All the nurses who can leave their posts, all the residents who have no patients on hand, all gather at the nurse's desk!" Director Liu shouted at the top of his voice in the emergency room, "Come and break the ampoules!"
The door of the rescue room was pushed open, and a blue flat trolley was pushed in by the pharmacy staff, "Director Liu, the atropine injection you want, here are five boxes, a total of [-]."
Sun Lien was taken aback by this number.
"Not enough, hurry up and move again." Urging the pharmacy to continue to deliver medicines, Director Liu asked the nurse to distribute a 6ml syringe to each of the doctors present, "You all know how to open the ampoule bottle, I won't talk nonsense Hurry up, the helicopter is expected to arrive on the apron in [-] minutes, before that, at least four people must gather atropine!"
The orderly organizational structure of the usually chaotic emergency room at the Fourth Central Hospital came into play.The senior nurses suddenly turned into shepherd dogs and began to drive the residents in white coats to cooperate with each other.Each nurse managed three residents at the same time, and they quickly knocked off the top of the ampoule in their hands with scissors.Groups of five broken ampoules were quickly stuffed into the hands of the resident physician.The injection solution was carefully inhaled into the syringe, and then the broken ampoule was thrown into the empty box on the spot. The next step was the second and third groups to open the vial and inhale the medicine.
Sun Li'en and Xu Yourong didn't join this team. The neurosurgeon's hands needed to be protected. The rough work of breaking ampoules was not suitable for Xu Yourong, and Sun Li'en was ordered by Director Liu.
"Go to the pharmacy right away and find Han Wenping, the director of the pharmacy department." Liu Tangchun called Sun Lien, "Tell him that I need at least [-] more atropine here. I don't care if he steals or robs, or just goes to the pharmaceutical factory Moving the warehouse, within an hour, I must see the medicine, do you understand?!"
Sun Li'en was about to go out, but suddenly heard Liu Tangchun shout behind him, "Tell Han Wenping, this is an order from Dean Song!"
Dean Song Wen has indeed issued an order.She received a call 2 minutes ago directly from the municipal party committee.Long Xinsheng, Secretary General of the Municipal Party Committee, made a direct request on the other end of the phone, "At all costs, we will do our best to cure these four heroic fire fighters."
The call ended quickly. At the end, Secretary-General Long deliberately emphasized again, "We must not let the hero bleed and cry, we must use the best measures, the most advanced methods!"
Now the most stressed person in the whole hospital is Dean Song Wen who received the call.When she answered the phone, Liu Tangchun was reporting the progress of the emergency response mechanism in the dean's office.In this way, Deputy Director Liu was arrested by his own director and dean.
"Director Han, I'm Sun Lien from the emergency department." Sun Lien pushed open the door of the pharmacy, where a group of pharmacists were moving boxes in the reserve warehouse.In order to facilitate their work, these doctors, who were not very strong, even took off their shirts, and ran back and forth among the shelves with their upper bodies shirtless.
After asking several people in succession, Sun Lien found Han Wenping, the director of the pharmacy department, who was shirtless and carrying boxes in the deepest part of the pharmacy.
"Director Liu said that the current dose of atropine is still not enough, and we must make up more than [-] atropine within two hours!" In order to better preserve the medicinal materials, the storage warehouse has always maintained a low temperature of about eight degrees.Director Han has a bald head, and his bald head is steaming upwards in the warehouse.In middle age, it is inevitable to have a beer belly, but Director Han's upper body muscles are still quite conspicuous - he looks like he can beat at least five Sun Lien.
"Isn't my mother looking for medicine?" Director Han wiped the sweat from his brow, cursing his mother, "The four are poisoned by organophosphate! I said last year that atropine was low, but no one believed it. !"
Sun Li'en didn't dare to get involved in the war of words of these directors, he was just faithfully fulfilling the duty of a small errand runner, "Director Liu said, whether you steal, rob, or simply move the warehouse of the pharmaceutical factory, atropine must Delivered." After a short pause, Sun Li'en continued, "Director Liu said, this is also what Dean Song meant."
There are two updates today, there may be a third update...but it is unlikely, Sanguan will pick up the airport tonight.It may be too late.
There will be a big cleaning tomorrow, there must be one update, but not necessarily the second update.
The editor said that I didn't recommend it because of the small number of words, so write as much as possible while you can.
Ask for tickets, ask for recommendations, ask for rewards!
(End of this chapter)
Knowing that four firefighters were unfortunately poisoned while performing their duties, Liu Tangchun immediately rushed to the emergency room to deploy work.
Unlike other types of illness, acute organophosphate inhalation poisoning can cause very severe respiratory and neurological damage.After organic phosphorus enters the blood through the lungs, it will inhibit acetylcholinesterase in the human body.The main function of acetylcholinesterase is to degrade acetylcholine.
Acetylcholine is a special substance that mainly acts on several special nervous systems in the human body.The sweat glands secreting nerves that control sweat secretion, all parasympathetic nerves, preganglionic fibers of sympathetic nerves, etc. transmit information through acetylcholine.The role of acetylcholinesterase is to terminate these signal transmissions at the appropriate time.
However, after the degradation function of acetylcholinesterase is prevented under the interference of organic phosphorus, excess acetylcholine is flooded in the nerves, and the secretion concentration is still increasing.Eventually, it will trigger systemic choline nerve excitement, and there is only one result after excessive excitement-failure.
The main cause of death of organophosphate poisoning is respiratory failure and coma caused by overexcited nerves.To rescue people from poisoning symptoms, it is first necessary to get out of the poison environment, and then immediately use anticholinergic drugs to help the body hydrolyze excess acetylcholine in the nervous system.
Atropine is the drug of choice for clinical rescue of organophosphate poisoning.
Atropine is usually used in rescue to relieve visceral colic, including gastrointestinal spasms, as well as sinus bradycardia and atrioventricular duct obstruction.Atropine extracted from belladonna or datura can block the response of choline nerves to acetylcholine, thereby preventing the over-excitation of choline nerves.
The reason why Liu Tangchun mobilized all the people to go to the emergency room to assign work was because of a somewhat speechless reason.
The dose of atropine injection produced by pharmaceutical factories is really too small, and the common specification of atropine injection is 0.5mg/1ml.In order to achieve the blocking effect, a patient needs at least 400 mg of atropine per hour, that is, at least 800 bottles of atropine injection are enough.
Large doses of atropine injections have not been produced for many years.The usual clinical use of atropine is mainly to take advantage of its spasmodic effect.Large doses of atropine injections do not seem to be necessary - after all, there are so few cases of organophosphate poisoning.
"All the nurses who can leave their posts, all the residents who have no patients on hand, all gather at the nurse's desk!" Director Liu shouted at the top of his voice in the emergency room, "Come and break the ampoules!"
The door of the rescue room was pushed open, and a blue flat trolley was pushed in by the pharmacy staff, "Director Liu, the atropine injection you want, here are five boxes, a total of [-]."
Sun Lien was taken aback by this number.
"Not enough, hurry up and move again." Urging the pharmacy to continue to deliver medicines, Director Liu asked the nurse to distribute a 6ml syringe to each of the doctors present, "You all know how to open the ampoule bottle, I won't talk nonsense Hurry up, the helicopter is expected to arrive on the apron in [-] minutes, before that, at least four people must gather atropine!"
The orderly organizational structure of the usually chaotic emergency room at the Fourth Central Hospital came into play.The senior nurses suddenly turned into shepherd dogs and began to drive the residents in white coats to cooperate with each other.Each nurse managed three residents at the same time, and they quickly knocked off the top of the ampoule in their hands with scissors.Groups of five broken ampoules were quickly stuffed into the hands of the resident physician.The injection solution was carefully inhaled into the syringe, and then the broken ampoule was thrown into the empty box on the spot. The next step was the second and third groups to open the vial and inhale the medicine.
Sun Li'en and Xu Yourong didn't join this team. The neurosurgeon's hands needed to be protected. The rough work of breaking ampoules was not suitable for Xu Yourong, and Sun Li'en was ordered by Director Liu.
"Go to the pharmacy right away and find Han Wenping, the director of the pharmacy department." Liu Tangchun called Sun Lien, "Tell him that I need at least [-] more atropine here. I don't care if he steals or robs, or just goes to the pharmaceutical factory Moving the warehouse, within an hour, I must see the medicine, do you understand?!"
Sun Li'en was about to go out, but suddenly heard Liu Tangchun shout behind him, "Tell Han Wenping, this is an order from Dean Song!"
Dean Song Wen has indeed issued an order.She received a call 2 minutes ago directly from the municipal party committee.Long Xinsheng, Secretary General of the Municipal Party Committee, made a direct request on the other end of the phone, "At all costs, we will do our best to cure these four heroic fire fighters."
The call ended quickly. At the end, Secretary-General Long deliberately emphasized again, "We must not let the hero bleed and cry, we must use the best measures, the most advanced methods!"
Now the most stressed person in the whole hospital is Dean Song Wen who received the call.When she answered the phone, Liu Tangchun was reporting the progress of the emergency response mechanism in the dean's office.In this way, Deputy Director Liu was arrested by his own director and dean.
"Director Han, I'm Sun Lien from the emergency department." Sun Lien pushed open the door of the pharmacy, where a group of pharmacists were moving boxes in the reserve warehouse.In order to facilitate their work, these doctors, who were not very strong, even took off their shirts, and ran back and forth among the shelves with their upper bodies shirtless.
After asking several people in succession, Sun Lien found Han Wenping, the director of the pharmacy department, who was shirtless and carrying boxes in the deepest part of the pharmacy.
"Director Liu said that the current dose of atropine is still not enough, and we must make up more than [-] atropine within two hours!" In order to better preserve the medicinal materials, the storage warehouse has always maintained a low temperature of about eight degrees.Director Han has a bald head, and his bald head is steaming upwards in the warehouse.In middle age, it is inevitable to have a beer belly, but Director Han's upper body muscles are still quite conspicuous - he looks like he can beat at least five Sun Lien.
"Isn't my mother looking for medicine?" Director Han wiped the sweat from his brow, cursing his mother, "The four are poisoned by organophosphate! I said last year that atropine was low, but no one believed it. !"
Sun Li'en didn't dare to get involved in the war of words of these directors, he was just faithfully fulfilling the duty of a small errand runner, "Director Liu said, whether you steal, rob, or simply move the warehouse of the pharmaceutical factory, atropine must Delivered." After a short pause, Sun Li'en continued, "Director Liu said, this is also what Dean Song meant."
There are two updates today, there may be a third update...but it is unlikely, Sanguan will pick up the airport tonight.It may be too late.
There will be a big cleaning tomorrow, there must be one update, but not necessarily the second update.
The editor said that I didn't recommend it because of the small number of words, so write as much as possible while you can.
Ask for tickets, ask for recommendations, ask for rewards!
(End of this chapter)
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